Established now is the idea that glucose-6-phosphate dehydrogenase deficiency is found in many other tissues including white blood cells, platelets, kidneys, adrenals, skin, saliva, sperm and liver. 1. 28.It is therefore not surprising that more and more disease states are now being attributed to the deficiency of this enzyme, or at least an attempt to do so. More often than not there appears to be no statistically significant relationship with glucose-6-phosphate dehydrogenase deficiency. A brief overview of the many areas and possibilities which have been looked into is given below.
The respiratory track is prone to many different diseases, both hereditary and infectious. A study was carried out in Zambia to determine any possible relationship between haemoglobin phenotype, glucose-6-phosphate dehydrogenase deficiency and bronchial asthma. The result of the study is that an association between Glucose-6-Phosphate Dehydrogenase Deficiency and bronchial asthma was not demonstrable. 13.A similar attempt to correlate narcotising pneumonia and glucose-6-phosphate dehydrogenase deficiency came to a negative conclusion. 29.In an unique situation is a case study on a child born to two Pakistani parents who was believed to be the first reported individual having both cystic fibrosis and glucose-6-phosphate dehydrogenase deficiency. This is very rare indeed because cystic fibrosis is exclusively a Caucasian congenital disease occurring in approximately 1 in 2000 births. Cystic fibrosis very seldom occurs in other races. 19.So is there a possible link between cystic fibrosis and glucose-6-phosphate dehydrogenase deficiency? This has yet to be determined.
A hospital based study demonstrated a significantly higher prevalence of glucose-6-phosphate dehydrogenase deficiency among Saudi Arabian patients with diabetes (18.4%) as opposed to healthy population control (2.0%). The cause is unknown to the authors. 30.In short, glucose-6-phosphate dehydrogenase activity is significantly lower in the diabetic than non-diabetic group. 31.
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Prepared on 01 Jan 2008 by teekoonhien |
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